Fluoxetine is an FDA-approved medication that has demonstrated efficacy in treating a spectrum of psychological conditions. These indications include major depressive disorder, obsessive-compulsive disorder, panic disorder, bulimia, binge eating disorder, premenstrual dysphoric disorder, and bipolar depression, including cases of treatment-resistant depression when combined with olanzapine. The mechanism of action involves the inhibition of serotonin reuptake in presynaptic neurons, achieved by blocking the reuptake transporter protein. This activity provides insights into fluoxetine's indications, off-label uses, mechanism of action, dosing, adverse effects, contraindications, monitoring, and toxicity.
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Maher AR, Theodore G. Maher AR, et al. J Manag Care Pharm. 2012 Jun;18(5 Suppl B):S1-20. doi: 10.18553/jmcp.2012.18.s5-b.1. J Manag Care Pharm. 2012. PMID: 22784311 Free PMC article. Review.
Sharbaf Shoar N, Fariba KA, Padhy RK. Sharbaf Shoar N, et al. 2023 Nov 7. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. 2023 Nov 7. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 29489221 Free Books & Documents.
Schwasinger-Schmidt TE, Macaluso M. Schwasinger-Schmidt TE, et al. Handb Exp Pharmacol. 2019;250:325-355. doi: 10.1007/164_2018_167. Handb Exp Pharmacol. 2019. PMID: 30194544
Masand PS, Gupta S. Masand PS, et al. Harv Rev Psychiatry. 1999 Jul-Aug;7(2):69-84. Harv Rev Psychiatry. 1999. PMID: 10471245 Review.
Singh HK, Saadabadi A. Singh HK, et al. 2023 Feb 13. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. 2023 Feb 13. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 31613469 Free Books & Documents.